Design, synthesis, and evaluations of antifungal activity of novel phenyl(2H-tetrazol-5-yl)methanamine derivatives

Journal of Chemical Biology

Amol B. Salake¹  M. K. Kathiravan¹  Abhishek A. Pandey¹  Madhavi Khilare¹  Shrikant S. Nilewar¹  Rutuja S. Meshram¹  Aparna S. Chothe¹ 

[1] Department of Pharmaceutical Chemistry (PG), AISSMS College of Pharmacy, Kennedy road, Near RTO, Pune, 411001 Maharashtra India

关键词: Phenyl(2H-tetrazol-5-yl)methanamine;    Fluconazole;    Antifungal agent;    Candida albicans;    Aspergillus niger;   

DOI  :  10.1007/s12154-013-0103-8

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

Fungal infections pose a continuous and serious threat to human health and life. The intrinsic resistance has been observed in many genera of fungi. Many fungal infections are caused by opportunistic pathogens that may be endogenous (Candida infections) or acquired from the environment (Cryptococcus and Aspergillus infections). So, new therapeutic strategies are needed to combat various fungal infections. Fluconazole shows good antifungal activity with relatively low toxicity and is preferred as first line antifungal therapy, but it has suffered from severe drug resistance. So, there is a need to design novel analogues by modification of fluconazole-like structure. A novel series of phenyl(2H-tetrazol-5-yl)methanamine derivatives were synthesized by reaction of α-amino nitrile with sodium azide and ZnCl2 in presence of isopropyl alcohol. They were evaluated for antifungal activity against Candida albicans and Aspergillus niger and subjected to docking study against 1EA1.

【 授权许可】

Unknown