Higher Sensitivity in LEC Rat Cells to a Topoisomerase II Inhibitor, Ellipticine

Journal of Veterinary Medical Science

Daiji ENDOH³  Yukako ICHIKAWA¹  Soichiro ARAI¹  Toyo OKUI²  Masanobu HAYASHI¹ 

[1] Department of Veterinary Radiology, Faculty of Veteriniary Medicine, Rakuno Gakuen University;Hokkaido Institute of Public Health;Department of Radiation Biology, Graduate School of Veterinary Medicine, Hokkaido University

关键词: ellipticine;    LEC strain rat;    topoisomerase II;   

DOI  :  10.1292/jvms.60.969

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(26)A concentration of ellipticine, an inhibitor of topoisomerase II, required to reduce cell survival to 37% (D37) is used as an index to compare the cellular sensitivity. D37 values of LEC and WKAH rat cells were 1.2 and 2.2 μM, respectively. Thus, LEC rat cells were approximately 1.8-fold more sensitive than WKAH rat cells to ellipticine. There was no significant difference between the topoisomerase II activities in nuclear extracts of LEC and WKAH rat cells. These results suggested that the high sensitivity of LEC rat cells to ellipticine is not associated with the level of topoisomerase II activity.

【 授权许可】

Unknown