Resistance to UV-Irradiation of DNA Synthesis in Fibroblast Cell Lines Derived from LEC Strain Rats

Journal of Veterinary Medical Science

Kazuhisa UEHARA²  Soichiro ARAI²  Toyo OKUI¹  Masanobu HAYASHI² 

[1] Hokkaido Institute of Public Health;Department of Veterinary Radiology, Faculty of Veterinary Medicine, Rakuno Gakuen University

关键词: LEC strain rat;    resistant DNA synthesis;    UV-irradiation;   

DOI  :  10.1292/jvms.59.67

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(26)Cited-By(2)After UV-irradiation, no difference in the survival curves was observed among cell lines derived from LEC strain (LEC) rats and WKAH strain (WKAH) rats. The dose-response curves for inhibition of DNA synthesis in WKAH-derived cells showed a sharp decline at lower doses and a mild decline at higher doses of UV-rays. In contrast, the dose-response curves in LEC-derived cell lines had no sharp component, and were almost identical to the mild component of the curves in WKAH-derived cells. These results show that DNA synthesis in the cell lines of LEC rats was more resistant to UV-irradiation than that of WKAH rats.

【 授权许可】

Unknown