Oral Mucosal Adhesive Films Containing Royal Jelly Accelerate Recovery From 5-Fluorouracil–Induced Oral Mucositis

Journal of Pharmacological Sciences

Hiroaki Kaji⁴  Kimie Imai³  Kenshi Takechi²  Hiroaki Araki²  Katsuya Suemaru¹  Shinichi Watanabe² 

[1] School of Pharmacy, Shujitsu University, Japan;Division of Pharmacy, Ehime University Hospital, Japan;Division of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Setsunan University, Japan;Division of Biochemistry, Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, Japan

关键词: antioxidant;    cancer;    5-fluorouracil;    oral mucositis;    royal jelly;   

DOI  :  10.1254/jphs.12181FP

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(35)Cited-By(7)Oral mucositis induced by chemotherapy or radiotherapy has an impact upon quality-of-life, is dose-limiting for chemotherapy, and causes considerable morbidity. We evaluated the effect of royal jelly (RJ) on 5-fluorouracil (5-FU)-induced oral mucositis in hamsters. Oral mucositis was induced in hamsters through a combination of 5-FU treatment and mild abrasion of the cheek pouch. RJ was contained in chitosan–sodium alginate film (RJ film). Films were attached to the oral mucosa and the healing process examined by measuring the area of mucositis, myeloperoxidase (MPO) activity, microscopic aspects, and RT-PCR for detection of pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-1β). Furthermore, we evaluated the radical-scavenging activity of RJ and generation of keratinocyte growth factor from human periodontal ligament fibroblasts. RJ films (10%, 30%) significantly improved recovery from 5-FU–induced damage, reduced MPO activity and the production of pro-inflammatory cytokines. Additionally, RJ showed radical-scavenging activity. These data suggest that topical application of films that contain RJ had a healing effect on the severe oral mucositis induced by 5-FU and that the effect was caused by the anti-inflammatory or anti-oxidative activities of RJ.

【 授权许可】

Unknown