Frequency of congenital craniofacial malformations in a Brazilian Reference Center

Revista Brasileira de Epidemiologia

Martelli-Júnior, Hercílio¹  Barros, Letízia Monteiro de¹  Miranda, Roseli Teixeira de¹  Ribeiro, Leila Aparecida¹  Paranaíba, Lívia Máris Ribeiro² 

[1] Dental School of University of Alfenas, Alfenas, Brazil;State University of Campinas, Piracicaba, Brazil

关键词: Congenital Anomalies;    Craniofacial Malformations;    Cleft Lip;    Cleft Palate;    Information Service;    Epidemiology;   

DOI  :  10.1590/S1415-790X2011000100014

学科分类：过敏症与临床免疫学

来源: SciELO

【 摘 要 】

OBJECTIVE:To evaluate the frequency of craniofacial anomalies in patients treated at aBrazilian Reference Center for craniofacial deformities.
METHOD: Retrospective epidemiological study evaluating the clinical recordsof 1,142 patients: 656 (57.4%) male and 486 (42.6%) female, between 1992 and2008.
RESULTS: Among birth defects, non-syndromic cleft lip and/or palate werethe most frequent ones (778 cases; 68.1%), followed by single or multiple congenitalanomalies without cleft lip and/or palate (240 cases; 21%), recognized syndromesor sequences (56 cases; 5%), syndromes with orofacial cleft as a component (41cases; 3.5%), and orofacial clefts in association with systemic malformations(27 cases; 2.4%).
CONCLUSIONS: Non-syndromic cleft lip and/or palate was the congenitaldefect most frequently identified, although, isolated anomalies and syndromesinvolving craniofacial structures were quite frequent. Furthermore, the needfor studies to identify the frequency and risk factors associated with craniofacialanomalies in the Brazilian population is emphasized in order to plan comprehensivestrategies and integrated actions for the development of preventive programsand treatment.

【 授权许可】

CC BY