Antioxidative and Antigenotoxic Effects of Japanese Horse Chestnut (Aesculus turbinata) Seeds

Journal of Veterinary Medical Science

Tadahiko SUZUKI²  Haruo KOBAYASHI²  Itaru SATO¹  Shuji TSUDA¹ 

[1] Laboratories of Veterinary Public Health, Faculty of Agriculture, Iwate University;Veterinary Pharmacology, Faculty of Agriculture, Iwate University

关键词: antigenotoxicity;    antioxidation;    Japanese horse chestnut;   

DOI  :  10.1292/jvms.67.731

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(30)Cited-By(13)Japanese horse chestnut seed extract (HCSE) dose-dependently inhibited the autooxidation of linoleic acid (IC50: 0.2 mg/ml), and the inhibition was almost complete at a concentration of 1 mg/ml. The HCSE scavenged DPPH (1,1-diphenyl-2-picrylhydrazyl) radicals and superoxide anions with EC50s of 0.65 and 0.21 mg/ml, respectively. However, it had no effect on hydrogen peroxide. The HCSE inhibited the genotoxicities of furylfuramide, N-methyl-N-nitrosourea, methyl methanesulfonate, mitomycin C, 2-aminoanthracene and aflatoxin B1 at a concentration of 1 mg/ml or more. Total polyphenol content of the HCSE was 21 mg/g (13 mg/g-seeds). These results indicate that the Japanese horse chestnut seed is an antioxidative and antimutagenic botanical resource.

【 授权许可】

Unknown