Effects of Polyphenols from Seed Shells of Japanese Horse Chestnut (Aesculus turbinata BLUME) on Methotrexate-Induced Intestinal Injury in Rats

Journal of Veterinary Medical Science

Satoshi OGAWA²  Takashi TAKEUCHI³  Kazushige YOKOTA¹  Hideto KIMURA²  Akihiko SUGIYAMA³ 

[1] Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University;Department of Research and Development, Kotobuki Seika Co., Ltd.;Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tottori University

关键词: intestinal injury;    Japanese horse chestnut;    methotrexate;    oxidative stress;   

DOI  :  10.1292/jvms.10-0423

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(32)Cited-By(1)The purpose of this study was to evaluate the effects of polyphenols from seed shells of Japanese horse chestnut (JHP) on methotrexate (MTX)-induced intestinal injury in rats. MTX application caused intestinal morphological injury and increase in malondialdehyde (MDA) levels, decrease in levels of glutathione (GSH) and glutathione peroxidase (GSH-Px) activities in small intestine. However, oral administration of JHP ameliorated MTX-induced intestinal injury and inhibited the increase in MDA and the decrease in GSH and GSH-Px activity in small intestine. In conclusion, our results indicated that oral administration of JHP alleviated MTX-induced intestinal injury through its antioxidant properties.

【 授权许可】

Unknown