Costimulatory Effects of Complement Receptor Type 3 and Fc Receptor for IgG (FcγR) on Superoxide Production and Signal Transduction in Bovine Neutrophils

Journal of Veterinary Medical Science

Hajime NAGAHATA¹  Mikinori KUWABARA²  Hidetoshi HIGUCHI¹  Osamu INANAMI² 

[1] Department of Animal Health, School of Veterinary Medicine, Rakuno Gakuen University;Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University

关键词: bovine neutrophils;    costimulation;    CR3;    FcγR;    signaling pathway;   

DOI  :  10.1292/jvms.69.993

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(20)Cited-By(2)The present study evaluated the costimulatory effects of complement receptor type 3 (CR3) and Fc receptor for IgG (FcγR) on superoxide production and intracellular signal transduction in bovine neutrophils. Stimulation with opsonized zymosan (OPZ) and heat-aggregated bovine IgG (Agg-IgG) resulted in much greater superoxide production and chemiluminescent (CL) responses in normal neutrophils compared with those stimulated with OPZ or Agg-IgG only. Superoxide production and CL response were closely associated with the stimulant-induced rise of the intracellular calcium ([Ca2+]i) concentration, amount of tyrosine phosphorylated 100 kDa protein, and activation of p38 mitogen-activated protein kinase (p38 MAPK). No costimulatory effect was found for these receptors on superoxide production in CR3-deficient neutrophils. Costimulation of CR3 and FcγR on bovine neutrophils leads to enhancement of superoxide production and their signaling pathways and appears to be associated with enhancement of neutrophil functions.

【 授权许可】

Unknown