A Case of Aldosterone-Producing Adrenocortical Adenoma Associated with Preclinical Cushing's Syndrome and Hypersecretion of Parathyroid Hormone

Endocrine Journal

SHINYA MAKINO²  FUMITO KOMATSU³  HIRONOBU SASANO¹  MOTONOBU YASUKAWA⁴  SHIGEHIKO ODA²  TOSHIHISA SAKA⁴ 

[1] Department of Pathology, Tohoku University School of Medicine;Department of Internal Medicine, Osaka Gyomeikan Hospital;Department of Urology, Kochi Medical School;Department of Urology, Osaka Gyomeikan Hospital

关键词: Primary aldosteronism;    Preclinical Cushing's syndrome;    Hyperparathyroidism;   

DOI  :  10.1507/endocrj.48.103

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(31)Cited-By(14)A rare case of aldosterone-producing adrenocortical adenoma with preclinical Cushing's syndrome and hypersecretion of parathyroid hormone (PTH) is described. A 64-year-old male patient had a history of hypertension for two decades and hypokalemia for 4 years. He suffered from left hemiparesis and aphasia due to cerebral hemorrhage, but his appearance was not Cushingoid. His plasma reamn activity was below the normal range, while plasma aldosterone concentration was high. They did not respond to furosemide-upright test. His plasma cortisol level in the morning was at the upper limit of the normal range, but it did not show a diurnal rhythm nor was it suppressed by 1mg and 8mg of dexamethasone. Computed tomography showed a low density tumor in the right adrenal gland. An adrenal scintigram under dexamethasone treatment revealed an uptake of the tracer on the right side, and plasma aldosterone and cortisol concentrations in the adrenal vein were higher on the right side than on the opposite. The diagnosis of right aldosterone-producing adrenal adenoma with an autonomous production of cortisol was confirmed by right adrenalectomy. Histological findings showed an adenoma consisting mostly of clear cells, but that the nests of compact cells were scattered. Analysis of an extract from the adenoma revealed that the adenoma contained an excess amount of aldosterone and that the cortisol/corticosterone ratio was higher than that of aldosterone-producing adenoma. Both serum calcium and PTH levels remained high one year after adrenalectomy. Ultrasonography revealed the swelling of a parathyroid gland on the left side, indicating the coexistence of an utonomous hyperparathyroidism.

【 授权许可】

Unknown