A Case of Preclinical Cushing's Syndrome Associated with Diurnal Rhythms of ACTH and Cortisol in Blood: Correlation with Histological Findings

Endocrine Journal

Hiroyuki USUDA³  Hironobu SASANO²  Kyuzi KAMOI⁴  Katsuaki ASAKAWA⁴  Hideo MORISHITA¹  Midori TANAKA⁴  Iwao EMURA³  Tomoo IKARASHI⁴  Takeshi KOMEYAMA¹  Masashi MIYAKOSHI⁴ 

[1] Department of Urology, Nagaoka Red Cross Hospital;Department of Pathology, Tohoku University School of Medicine;Department of Pathology, Nagaoka Red Cross Hospital;Department of Internal Medicine, Division of Endocrine and Metabolism, Nagaoka Red Cross Hospital

关键词: Preclinical Cushing's syndrome;    Diurnal rhythms of cortisol and ACTH;    Histology of adrenal gland;   

DOI  :  10.1507/endocrj.K06-088

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(13)Cited-By(2)We describe a case of adrenocortical adenoma with preclinical Cushing's syndrome demonstrating diurnal rhythms of ACTH and cortisol in blood. A 50-year-old man was admitted to the hospital for the evaluation of incidental right adrenal mass with hyperglycemia and hypertension. On admission, there were no signs of clinical manifestation of hypercortisolism. The basal levels of cortisol (9.3 μg/dl) and ACTH (9.4 pg/ml) at 0800 h were not elevated and these diurnal rhythms were maintained. One or 8 mg of dexamethasone given orally overnight suppressed the plasma ACTH but not serum cortisol. Ultrasonogram, CT and scintiscan of 131I adosterol all demonstrated an enlarged adrenal mass in the right adrenal gland. The right adrenal gland was subsequently resected by laparoscopic surgery. Histopathological findings of resected adrenal tumor were consistent with adrenocortical adenoma. Adjacent non-neoplastic adrenal tissue demonstrated adrenocortical atrophy but DHEA-sulfotransferase immunoreactivity in the zona reticularis was detected.

【 授权许可】

Unknown