Endocrine Journal | |
A Case of Preclinical Cushing's Syndrome Associated with Diurnal Rhythms of ACTH and Cortisol in Blood: Correlation with Histological Findings | |
Hiroyuki USUDA3  Hironobu SASANO2  Kyuzi KAMOI4  Katsuaki ASAKAWA4  Hideo MORISHITA1  Midori TANAKA4  Iwao EMURA3  Tomoo IKARASHI4  Takeshi KOMEYAMA1  Masashi MIYAKOSHI4  | |
[1] Department of Urology, Nagaoka Red Cross Hospital;Department of Pathology, Tohoku University School of Medicine;Department of Pathology, Nagaoka Red Cross Hospital;Department of Internal Medicine, Division of Endocrine and Metabolism, Nagaoka Red Cross Hospital | |
关键词: Preclinical Cushing's syndrome; Diurnal rhythms of cortisol and ACTH; Histology of adrenal gland; | |
DOI : 10.1507/endocrj.K06-088 | |
学科分类:内分泌与代谢学 | |
来源: Japan Endocrine Society | |
【 摘 要 】
References(13)Cited-By(2)We describe a case of adrenocortical adenoma with preclinical Cushing's syndrome demonstrating diurnal rhythms of ACTH and cortisol in blood. A 50-year-old man was admitted to the hospital for the evaluation of incidental right adrenal mass with hyperglycemia and hypertension. On admission, there were no signs of clinical manifestation of hypercortisolism. The basal levels of cortisol (9.3 μg/dl) and ACTH (9.4 pg/ml) at 0800 h were not elevated and these diurnal rhythms were maintained. One or 8 mg of dexamethasone given orally overnight suppressed the plasma ACTH but not serum cortisol. Ultrasonogram, CT and scintiscan of 131I adosterol all demonstrated an enlarged adrenal mass in the right adrenal gland. The right adrenal gland was subsequently resected by laparoscopic surgery. Histopathological findings of resected adrenal tumor were consistent with adrenocortical adenoma. Adjacent non-neoplastic adrenal tissue demonstrated adrenocortical atrophy but DHEA-sulfotransferase immunoreactivity in the zona reticularis was detected.
【 授权许可】
Unknown
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