Regulation of Cholesterol Metabolism in Adrenal Cortex

Endocrine Journal

KEIJI MIKAMI²  MASAO OMURA³  AKIKO YOSHIDA¹  YASUSHI SAITO¹  YASUSHI TAMURA¹  TETSUO NISHIKAWA³ 

[1] Second Department of Internal Medicine, School of Medicine, Chiba University;Department of Medicine, Chiba Municipal Hospital;Department of Medicine, Yokohama Rosai Hospital

关键词: Rat adrenal;    Cholesterol esterase;    Apoproteins;   

DOI  :  10.1507/endocrj.40.221

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(25)Cited-By(3)We have investigated the effects of apoproteins on cholesterol esterase (CEase) in rat adrenal glands in order to clarify the mechanism of synthesis of free cholesterol which is the most important substrate for steroidogenesis. We prepared lipid mixtures containing cholesteryl oleate plus apoproteins with and without phosphatidylcholine as a substrate for CEase in order to investigate the effect of the substrate state on CEase. The substrate containing only cholesteryl oleate and apo-HDL increased both acid and alkaline CEase activities. Both acid and alkaline CEase activities were also increased by a substrate containing apo-HDL plus cholesteryl oleate and phosphatidylcholine more than by a substrate containing cholesteryl oleate plus apo-LDL with phosphatidylcholine or cholesteryl oleate with phosphatidylcholine. We have already reported that phosphatidylcholine is an important factor for the regulation of adrenal CEase. Therefore, the present studies show that apoproteins as well as phosphatidylcholine may be important factors for the regulation of adrenal CEase.

【 授权许可】

Unknown