Oxidative Stress, Inflammation, and Atherosclerotic Changes in Retinal Arteries in the Japanese Population; Results from the Mima Study

Endocrine Journal

Kyoko SAIGA²  Naoki SAKANE²  Yukiyo MATSUOKA²  Shinji FUJIWARA¹  Kazuhiko KOTANI²  Taku HAMADA²  Yoshiko SANO²  Kokoro TSUZAKI²  Masayuki DOMICHI² 

[1] Mima City National Health Insurance Koyadaira Clinic;Division of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center

关键词: Oxidative stress;    C-reactive proteins;    Atherosclerosis;    General population;   

DOI  :  10.1507/endocrj.K07E-073

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(17)Cited-By(13)Oxidative stress and inflammation are known to play roles in the pathogenesis of vascular events. The aim of this study was to investigate the relationship between oxidative stress, inflammation, and atherosclerosis in the general population. A population-based, cross-sectional study was made of 282 people (126 men and 156 women, mean age; 65 13, mean BMI; 25.4 2.7 kg/m 2 ) recruited from the Mima study in Tokushima Prefecture. Risk factors included age, sex, body mass index (BMI), cigarette smoking, systolic and diastolic pressure, fasting blood glucose, serum lipids, and high-sensitive C-reactive protein (hs-CRP). Oxidative stress in blood samples was measured by the diacron reactive oxygen metabolites (ROMs) test. The degree of sclerotic change was determined from fundus photographs according to Scheie's classification. After adjustment for age and sex, ROM levels positively correlated with hs-CRP levels, but not with ghrelin, leptin and adiponectin levels. Furthermore, ROM and hs-CRP levels positively and individually correlated with the grade of sclerotic change in the fundus oculi independent of age in a multiple regression analysis. These results suggest that oxidative stress and chronic inflammation promote atherosclerosis in the retinal arteries in the general population.

【 授权许可】

Unknown