Bone Formation With the Combination of Simvastatin and Calcium Sulfate in Critical-Sized Rat Calvarial Defect

Journal of Pharmacological Sciences

Takahiro Nakamura¹  Mitsumasa Oda¹  Myat Nyan¹  Hiroshi Kobayashi¹  Tetsu Machida¹  Daisuke Sato¹  Shohei Kasugai¹ 

[1] Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University, Japan

关键词: simvastatin;    calcium sulfate;    bone formation;   

DOI  :  10.1254/jphs.SC0070184

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(13)Cited-By(53)Simvastatin, a cholesterol synthesis inhibitor, enhances BMP2 expression in osteoblasts. The purpose of the present study was to examine whether simvastatin stimulates bone regeneration when combined with calcium sulfate as a carrier. Critical-sized bone defects in rat calvaria were treated with calcium sulfate or with combination of 1 mg simvastatin and calcium sulfate. In the combination group, although the least amount of bone formation with intense soft tissue inflammation was observed at 2 and 4 weeks, remarkable bone formation was evident at 8 weeks. Conclusively, the combination of simvastatin and calcium sulfate stimulated bone regeneration in spite of the inflammatory response.

【 授权许可】

Unknown