Lack of Association of LRP5 and LRP6 Polymorphisms with Type 2 Diabetes Mellitus in the Japanese Population

Endocrine Journal

Masako ZENIBAYASHI²  Kazuaki MIYAKE²  Tetsuya TERANISHI²  Kazuhiko SAKAGUCHI²  Jun TAKEDA¹  Kunichi KOUYAMA²  Yushi HIROTA²  Masato KASUGA²  Yukio HORIKAWA¹ 

[1] Department of Diabetes and Endocrinology, Division of Molecule and Structure, Gifu University School of Medicine;Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine

关键词: LRP5;    LRP6;    Single nucleotide polymorphism;    Association study;    Type 2 diabetes mellitus;   

DOI  :  10.1507/endocrj.K08E-021

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(25)Cited-By(4)Aims. A missense mutation in the low density lipoprotein receptor-related protein 6 gene (LRP6) was recently shown to be responsible for a disorder characterized by early-onset coronary artery disease as well as diabetes mellitus (DM), hyperlipidemia, hypertension, and osteoporosis. Mice deficient in LRP5, a closely related paralog of LRP6, manifest a marked impairment in glucose tolerance. The aim of the present study was to examine whether common variants of LRP5 and LRP6 are associated with Type 2 DM or dyslipidemia in Japanese individuals. Methods. Thirteen single nucleotide polymorphisms (SNPs) of LRP6 and nine SNPs of LRP5 were genotyped in a total of 608 Type 2 DM patients and 366 nondiabetic control subjects (initial study). An association analysis was then performed for each SNP and for haplotypes. For some of the SNPs, we provided another sample panel of 576 cases and 576 controls for the replication study. The relation to clinical characteristics was also examined in diabetic subjects. Results. In the initial study, three SNPs of LRP6 were found to be associated with susceptibility to Type 2 DM. However, this association was not detected in the replication panel. None of SNPs in LRP5 were associated with Type 2 DM in the initial panel. Neither LRP6 nor LRP5 was associated with body mass index, HOMA-β, HOMA-IR or serum lipid concentrations. Conclusions. We found no evidence for a substantial effect of LRP5 or LRP6 SNPs on susceptibility to type 2 diabetes or clinical characteristics of diabetic subjects in Japanese population.

【 授权许可】

Unknown