Investigation of the ZNF804A gene polymorphism with genetic risk for bipolar disorder in attention deficit hyperactivity disorder

BMC Research Notes

Philip Asherson¹  Yu-Yu Wu³  Yu-Shu Huang³  Ursula M Paredes¹  Chih-Ken Chen³  Bo Sun²  Lucy Luo²  Gerome Breen¹  Xiaohui Xu¹ 

[1] MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King’s College London, London, UK;School of Medicine, King’s College London, London, UK;Division of Mental Health & Drug Abuse Research, National Health Research Institutes, Taoyuan, Taiwan

关键词: Bipolar disorder;    Association study;    Single nucleotide polymorphism;    ZNF804A;    Attention deficit hyperactivity disorder;   

Others  :  1144926
DOI  :  10.1186/1756-0500-6-29

 received in 2012-07-10, accepted in 2013-01-23,  发布年份 2013

【 摘 要 】

Background

Genome-wide association studies (GWAS) have been conducted on many psychiatric disorders. Evidence from large GWAS indicates that the single nucleotide polymorphism (SNP) rs1344706 in the zinc-finger protein 804A gene (ZNF804A) is associated with psychotic disorders including bipolar disorder and schizophrenia. One study also found significant association between rs1344706 and the executive control network of attention. In this study we examine the role of the rs1344706 polymorphism that previously showed association with BD and is known to alter expression of the gene in two clinical family-based ADHD samples from the UK and Taiwan.

Findings

To investigate the association between rs1344706 and ADHD, two family samples of ADHD probands from the United Kingdom (n = 180) and Taiwan (n = 212) were genotyped using TaqMan SNP genotyping assays and analysed using within-family transmission disequilibrium test. No significant associations were found between rs1344706 polymorphism and ADHD in either of the samples from Taiwan (P = 0.91) and UK (P = 0.41). Even combining the two datasets together the A allele of rs1344706 SNP was still not significantly over-transmitted to affected probands (P = 0.50). Furthermore, there was no evidence of association with the specific symptoms subgroups of inattention or hyperactivity-impulsivity.

Conclusions

In this study we used family-based ADHD data in the UK and Taiwanese population to test for an association between rs1344706 SNP in the ZNF804A gene and ADHD. Results showed no significant association of rs1344706 with ADHD in UK and Taiwanese samples.

【 授权许可】

   
2013 Xu et al.; licensee BioMed Central Ltd.

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