Establishment and Characterization of Four Canine Melanoma Cell Lines

Journal of Veterinary Medical Science

Sung-Hyeok HONG¹  Kaori INOUE²  Satoru MATSUNAGA¹  Tsuyoshi KADOSAWA³  Nobuo SASAKI¹  Ryohei NISHIMURA¹  Manabu MOCHIZUKI¹  Emi OHASHI¹ 

[1] Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo;Biological Research Laboratories, Sankyo Co., Ltd.;School of Veterinary Medicine, Rakuno Gakuen University

关键词: canine;    melanoma;    xenotransplantation;   

DOI  :  10.1292/jvms.66.1437

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(10)Cited-By(11)Four canine melanoma cell lines were established from the subcutaneous, oral gingival and mucosal melanoma tissues at the primary and metastatic sites. These cell lines were designated as CMeC-1, CMeC-2, KMeC and LMeC. The cells were spindles in shape, similar to that of primary tumor cells. The doubling times of these cells ranged from 34.1 ± 5.61 to 57.9 ± 3.28 hr and their chromosome number ranged from 46 to 80. When transplanted into nude mice, CMeC-1 and LMeC produced tumors, whereas CMeC-2 and KMeC did not. The morphology of the tissue formed by xenotransplantation of these cells was similar to their primary tumors.

【 授权许可】

Unknown