Anaplastic Gangliocytoma with Eosinophilic Cytoplasmic Granules in a Cow

Journal of Veterinary Medical Science

Koichi Kadota³  Yoshiharu Ishikawa³  Hiroshi Kondo²  Kozo Kimura⁴  Yoshihiro Wada¹ 

[1] Rumoi Livestock Hygiene Service Center, 11 Miyazonomachi, Horonobe, Hokkaido 098-3207, Japan;Ishikari Livestock Hygiene Service Center, 3 Hitsujigaoka, Toyohira, Sapporo 062-0045, Japan;Hokkaido Research Station, National Institute of Animal Health, 4 Hitsujigaoka, Toyohira, Sapporo 062-0045, Japan;Nemuro Livestock Hygiene Service Center, 69 Betsukaimidorimachi, Betsukai, Hokkaido 086-0214, Japan

关键词: bovine;    brain;    gangliocytoma;   

DOI  :  10.1292/jvms.61.983

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(14)Cited-By(1)In a 3-year-old Holstein cow, a tumor mass replaced the left olfactory bulb. The tumor was highly or moderately cellular, and consisted of tumor cells showing pleomorphism and anaplasia, sometimes with intracytoplasmic granules. The tumor showed weak reactivity for neurofilaments (NF) in most cells with distinct staining in a minority, and it was extremely rare to see neoplastic cells with positivity for glial fibrillary acidic protein (GFAP). The neoplastic cells displayed some ultrastructural features reminiscent of ganglionic cells, and the cytoplasmic granularity was due to the presence of numerous lysosomes. This tumor expressing both NF and GFAP may be histogenetically related to brain tumors of pluripotential cell origin in calves.

【 授权许可】

Unknown