Vitamin D Receptor Gene Polymorphism in Japanese Patients with Prostate Cancer

Endocrine Journal

KOICHIRO AKAKURA²  YUZO FURUYA¹  MOTOYUKI MASAI¹  HARUO ITO² 

[1] Department of Urology, Teikyo University School of Medicine;Department of Urology, School of Medicine, Chiba University

关键词: Prostate cancer;    Vitamin D receptor;    Polymorphism;   

DOI  :  10.1507/endocrj.46.467

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(22)Cited-By(15)Vitamin D receptor gene polymorphism was determined in 66 and 60 Japanese patients with prostate cancer and non cancer controls, respectively. In contrast to previous reports showing an association between vitamin D receptor polymorphism of a TaqI restriction fragment length polymorphism at codon 352 (genotype tt) and prostate cancer in an American population, the frequency of genotype tt is less than one percent in the Japanese population. There was no difference between the patients and the controls in the vitamin D receptor TaqI genotype. In patients with metastatic prostate cancer, genotype TT had a tendency to shorter progression free survival compared to genotype Tt, but the number of patients was limited

【 授权许可】

Unknown