Associations of vitamin D deficiency and vitamin D receptor (Cdx-2, Fok I, Bsm I and Taq I) polymorphisms with the risk of primary open-angle glaucoma

BMC Ophthalmology

Research Article

Hua Liu¹  Jian Ji¹  Xiaorong Li¹  Wenjiang Ma¹  Yingjuan Lv¹  Qingbin Yao² 

[1] Department of Glaucoma, Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute, The School of Optometry&Ophthalmology, No.251 Fu Kang Road, Nan kai District, 300384, Tianjin, China;Department of Histology and Embryology, Tianjin Medical University, No. 22 Qi Xiang Tai Road, He Ping District, 300070, Tianjin, China;

关键词: Vitamin D deficiency;    Vitamin D receptor;    Polymorphism;    Primary open-angle glaucoma;   

DOI  :  10.1186/s12886-016-0289-y

 received in 2015-11-08, accepted in 2016-07-05,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundVitamin D deficiency and vitamin D receptor gene polymorphisms are known to be significantly associated with high myopia. Whether this genetic variant may impact primary open-angle glaucoma is largely unknown. This study investigated whether vitamin D receptor gene polymorphisms are altered in primary open-angle glaucoma subjects carrying the risk allele, and whether vitamin D deficiency is an important factor in the development of glaucoma.MethodsSeventy-three POAG patients and 71 age-matched controls from the Han population were enrolled. Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by enzyme-linked immunoabsorbent assay. Vitamin D receptor polymorphisms (Cdx-2, Fok I, Bsm I and Taq I) were analyzed using real-time polymerase-chain reaction high resolution melting analysis.ResultsSerum levels of 1a, 25-Dihydroxyvitamin in primary open-angle glaucoma patients were lower than in age-matched controls. Statistical analysis revealed a significant difference in the allelic frequencies of the BsmI and TaqI genotypes between primary open-angle glaucoma patients and age-matched controls, while other polymorphisms did not show any significant differences.ConclusionsVitamin D deficiency and the presence of the BsmI ‘B’ allele and the TaqI ‘t’ allele are relevant risk factors in the development of glaucoma.Trial registrationClinical Trials.gov: NCT02539745.The study was registered retrospectively on August 3rd, 2015. The first participant was enrolled on July 4th, 2013.

【 授权许可】

CC BY   
© The Author(s). 2016