Journal of Veterinary Medical Science | |
Combination of serum phosphorylated neurofilament heavy subunit andhyperintensity of intramedullary T2W on magnetic resonance imaging provides betterprognostic value of canine thoracolumbar intervertebral disc herniation | |
Jun YASUDA1  Yui KOBATAKE1  Takashi UEMURA2  Yuji UZUKA1  Hiroaki KAMISHINA1  Tsuyoshi OZAWA2  Tadahisa MASHITA5  Naoki KITAMURA4  Shunsuke SHIMAMURA1  Ataru NAKANISHI5  Sadatoshi MAEDA1  Yusuke HARASAKI5  Gerry SHAW3  Yosuke AKAGI5  Yuya NAKAMOTO2  | |
[1] Department of Clinical Veterinary Science, The United Graduate School of Veterinary Science, Gifu University, 1�?1 Yanagito, Gifu 509-1193, Japan;Kyoto Animal Referral Center, 208�?4 Taishinarami, Kyoto 613-0036, Japan;Department of Neuroscience, University of Florida, College of Medicine, Gainesville, FL 32611, U.S.A.;Laboratory of Veterinary Physiology, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, 4�?101 Koyamacho Minami, Tottori 680-8553, Japan;Maizuru Animal Medical Center, 8�?22 Hamamachi, Maizuru, Kyoto 625-0037, Japan | |
关键词: canine; intervertebral disc herniation; MRI; neurofilament heavy subunit; T2W hyperintensity; | |
DOI : 10.1292/jvms.14-0582 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
References(30)The aim of this study was to evaluate the prognostic value of concurrent measurement ofserum phosphorylated neurofilament heavy subunit (pNF-H) concentration and intramedullaryT2W hyperintensity in paraplegic to paraplegic dogs. Our hypothesis was that concurrentmeasurement of these would provide a more accurate prediction of functional outcome indogs with thoracolumbar intervertebral disc herniation (IVDH). A prospective case-controlclinical study was designed using 94 dogs with acute onset of thoracolumbar IVDH. Theassociation of serum pNF-H concentration, T2W hyperintensity on sagittal MRI (T2H/L2),deep pain perception and surgical outcome were evaluated with logistic regression analysisafter three months for all 94 surgically treated dogs. Sensitivity to predictnon-ambulatory outcome was compared among pNF-H and T2H/L2 and combination of both.Logistic regression analysis indicated that serum pNF-H concentration and T2H/L2 weresignificantly correlated with surgical outcome (P<0.05); however, deeppain perception was not (P=0.41). The results of logistic regressionanalysis indicated that the odds ratios of unsuccessful long-term outcome were 2.6 forserum pNF-H concentration, 1.9 for T2H/L2 and 2.3 for deep pain sensation. The sensitivityand specificity to predict non-ambulatory outcome for using serum parameter pNF-H>2.6ng/ml, using T2H/L2 value of>0.84 and using bothserum pNF-H and T2H/L2, were 95% and 75.7%, 65% and 86.5%, and 90.0% and 97.5%,respectively. Therefore, combined measurements of serum pNF-H and T2H/L2 might be usefulfor predicting long-term outcome in dogs with thoracolumbar IVDH.
【 授权许可】
Unknown
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