Combination of serum phosphorylated neurofilament heavy subunit andhyperintensity of intramedullary T2W on magnetic resonance imaging provides betterprognostic value of canine thoracolumbar intervertebral disc herniation

Journal of Veterinary Medical Science

Jun YASUDA¹  Yui KOBATAKE¹  Takashi UEMURA²  Yuji UZUKA¹  Hiroaki KAMISHINA¹  Tsuyoshi OZAWA²  Tadahisa MASHITA⁵  Naoki KITAMURA⁴  Shunsuke SHIMAMURA¹  Ataru NAKANISHI⁵  Sadatoshi MAEDA¹  Yusuke HARASAKI⁵  Gerry SHAW³  Yosuke AKAGI⁵  Yuya NAKAMOTO² 

[1] Department of Clinical Veterinary Science, The United Graduate School of Veterinary Science, Gifu University, 1�?1 Yanagito, Gifu 509-1193, Japan;Kyoto Animal Referral Center, 208�?4 Taishinarami, Kyoto 613-0036, Japan;Department of Neuroscience, University of Florida, College of Medicine, Gainesville, FL 32611, U.S.A.;Laboratory of Veterinary Physiology, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, 4�?101 Koyamacho Minami, Tottori 680-8553, Japan;Maizuru Animal Medical Center, 8�?22 Hamamachi, Maizuru, Kyoto 625-0037, Japan

关键词: canine;    intervertebral disc herniation;    MRI;    neurofilament heavy subunit;    T2W hyperintensity;   

DOI  :  10.1292/jvms.14-0582

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(30)The aim of this study was to evaluate the prognostic value of concurrent measurement ofserum phosphorylated neurofilament heavy subunit (pNF-H) concentration and intramedullaryT2W hyperintensity in paraplegic to paraplegic dogs. Our hypothesis was that concurrentmeasurement of these would provide a more accurate prediction of functional outcome indogs with thoracolumbar intervertebral disc herniation (IVDH). A prospective case-controlclinical study was designed using 94 dogs with acute onset of thoracolumbar IVDH. Theassociation of serum pNF-H concentration, T2W hyperintensity on sagittal MRI (T2H/L2),deep pain perception and surgical outcome were evaluated with logistic regression analysisafter three months for all 94 surgically treated dogs. Sensitivity to predictnon-ambulatory outcome was compared among pNF-H and T2H/L2 and combination of both.Logistic regression analysis indicated that serum pNF-H concentration and T2H/L2 weresignificantly correlated with surgical outcome (P<0.05); however, deeppain perception was not (P=0.41). The results of logistic regressionanalysis indicated that the odds ratios of unsuccessful long-term outcome were 2.6 forserum pNF-H concentration, 1.9 for T2H/L2 and 2.3 for deep pain sensation. The sensitivityand specificity to predict non-ambulatory outcome for using serum parameter pNF-H>2.6ng/ml, using T2H/L2 value of>0.84 and using bothserum pNF-H and T2H/L2, were 95% and 75.7%, 65% and 86.5%, and 90.0% and 97.5%,respectively. Therefore, combined measurements of serum pNF-H and T2H/L2 might be usefulfor predicting long-term outcome in dogs with thoracolumbar IVDH.

【 授权许可】

Unknown