Decreased Concentration of Serum Apolipoprotein C-III in Cows with Fatty Liver, Ketosis, Left Displacement of the Abomasum, Milk Fever and Retained Placenta

Journal of Veterinary Medical Science

Midori YAMAMOTO²  Hisami NAKAGAWA-UETA³  Norio KATOH¹  Shin OIKAWA⁴ 

[1] Hokkaido Research Station, National Institute of Animal Health;The Fukushima Kenchu Livestock Hygiene Service Center;The Ishikawa Hokubu Livestock Hygiene Service Center;The Department of Veterinary Internal Medicine, Rakuno Gakuen University

关键词: apolipoprotein C-III;    bovine;    fatty liver;    high-density lipoprotein;    postparturient disease.;   

DOI  :  10.1292/jvms.63.227

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(37)Cited-By(7)Apolipoprotein (apo) C-III is a low molecular mass protein mainly distributed in the high-density lipoprotein (HDL) fraction. In cows with postparturient diseases such as ketosis, concentrations of cholesterol, phospholipids and apoA-I and the activity of lecithin:cholesterol acyltransferase, which are mainly distributed in or functionally associated with HDL, are reduced. The purpose of the present study was to examine whether the serum concentration of apoC-III was similarly decreased in the postparturient diseases. Compared with healthy controls, the apoC-III concentration was significantly (P<0.01) decreased in cows with fatty liver, ketosis, left displacement of the abomasum, milk fever and retained placenta. Concentrations of apoC-III in the HDL fractions from diseased cows were also lower than in controls. Of the diseased cows, the decreased apoC-III concentration was particularly distinct in cows with milk fever. Increased nonesterified fatty acid and reduced free cholesterol, cholesteryl ester and phospholipid concentrations were observed in cows with milk fever, as in the other diseased cows. The decrease in the apoC-III concentration is suggested to be closely associated with the postparturient disorders, in particular with milk fever.

【 授权许可】

Unknown