Influence of different commercial scaffolds on the in vitro differentiation of human mesenchymal stem cells to nucleus pulposus-like cells

European Spine Journal

Marco Mehr¹  Martin Baur¹  Niklaus Aebli¹  Jivko V. Stoyanov¹  Alessandro Bertolo¹  Stephen J. Ferguson¹ 

[1] Swiss Paraplegic Research, 6207 Nottwil, Switzerland

关键词: Mesenchymal stem cells;    Chondrogenesis;    Intervertebral disc;    Nucleus pulposus and three-dimensional cultures;   

DOI  :  10.1007/s00586-011-1975-3

学科分类：骨科学

来源: Springer

【 摘 要 】

Cell-based therapies for regeneration of the degenerated intervertebral disc (IVD) are an alternative to current surgical intervention. Mesenchymal stem cells (MSCs), in combination with a scaffold, might be ideal candidates for regenerating nucleus pulposus (NP), the pressure-distributing part of the IVD. While the use of growth factors for MSCs differentiation currently receives major attention, in this study we compare the performance of sponge-like matrixes in supporting cell differentiation into NP-like cells.

【 授权许可】

Unknown