Hepatoprotective action of dry aqueous extract from Boerhavia erecta L. (toston) in rats

Revista Cubana de Plantas Medicinales

Carrillo Domínguez, Carmen¹  Valdés Martínez, Odalys¹  Agüero Fernández, Sara¹  Tillán Capó, Juana I.¹  Bueno Pavón, Viviana¹ 

[1] Centro de Investigación y Desarrollo de Medicamentos, Ciudad de La Habana, Cuba

关键词: : rats;    Boerhavia erecta;    hepatoprotective;   

DOI  :  

学科分类：药理学

来源: Editorial Ciencias Medicas

【 摘 要 】

INTRODUCTION: several in vitro studies of the aqueous extract from Boerhavia erecta L. and the human hepatome cell line PLC/PRF/5 showed suppression in the formation of hepatitis B surface antigen (HbsAg) and the inhibitory action of the antigen present in human serum contaminated with hepatitis B surface antigen. OBJECTIVES: to determine the in vivo hepatoprotective effect of the aqueous extract from B. erecta. METHODS: male Wistar rats were treated with 250 and 500mg of dry extract per kg intragastrically for 5 days, with induced hepatic damage on the last day, using 1 ml/kg of a 1:1 mixture of carbon tetrachloride and olive oil; after 24 hours, blood samples were taken to determine enzymatic activity of alanine-aminotransferase and for the euthanasia of the rats in order to perform the histological study of their livers. RESULTS: the extract caused significant reduction in the enzymatic activity of alanine-aminotransferase from treated rat sera and provided complete protection to the parenchyma of those animals which were administered 500 mg/kg dose. CONCLUSIONS: the in vivo hepatoprotective effect of B. erecta aqueous extract was shown against carbon tetrachloride-induced damage.

【 授权许可】

CC BY-NC