Revista Cubana de Plantas Medicinales | |
Hepatoprotective action of dry aqueous extract from Boerhavia erecta L. (toston) in rats | |
Carrillo Domínguez, Carmen1  Valdés Martínez, Odalys1  Agüero Fernández, Sara1  Tillán Capó, Juana I.1  Bueno Pavón, Viviana1  | |
[1] Centro de Investigación y Desarrollo de Medicamentos, Ciudad de La Habana, Cuba | |
关键词: : rats; Boerhavia erecta; hepatoprotective; | |
DOI : | |
学科分类:药理学 | |
来源: Editorial Ciencias Medicas | |
【 摘 要 】
INTRODUCTION: several in vitro studies of the aqueous extract from Boerhavia erecta L. and the human hepatome cell line PLC/PRF/5 showed suppression in the formation of hepatitis B surface antigen (HbsAg) and the inhibitory action of the antigen present in human serum contaminated with hepatitis B surface antigen. OBJECTIVES: to determine the in vivo hepatoprotective effect of the aqueous extract from B. erecta. METHODS: male Wistar rats were treated with 250 and 500mg of dry extract per kg intragastrically for 5 days, with induced hepatic damage on the last day, using 1 ml/kg of a 1:1 mixture of carbon tetrachloride and olive oil; after 24 hours, blood samples were taken to determine enzymatic activity of alanine-aminotransferase and for the euthanasia of the rats in order to perform the histological study of their livers. RESULTS: the extract caused significant reduction in the enzymatic activity of alanine-aminotransferase from treated rat sera and provided complete protection to the parenchyma of those animals which were administered 500 mg/kg dose. CONCLUSIONS: the in vivo hepatoprotective effect of B. erecta aqueous extract was shown against carbon tetrachloride-induced damage.
【 授权许可】
CC BY-NC
【 预 览 】
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