A Field Trial of Oil Adjuvanten Trivalent Actinobacillus pleuropneumoniae Vaccine

Journal of Veterinary Medical Science

Eiji OISHI¹  Hisae NAKAMURA¹  Takashi KITAJIMA¹  Chieko MATSUDA¹  Katsuhiko AMIMOTO¹  Hisao YASUHARA¹ 

[1] Division of Veterinary Microbiology Kyoto Biken Laboratories

关键词: Actinobacillus pleuropneumoniae;    field trial;    vaccine;   

DOI  :  10.1292/jvms.59.421

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(14)Cited-By(1)The trivalent vaccine of A. pleuropneumoniae serotype 1, 2 and 5 (AP3V) was prepared in the oil-in-water type adjuvanten form. At an SPF farm, the vaccinated pigs were observed for their antibody response, finishing rate, and lung lesions at the time of slaughter and for injection scars. The CF titers against serotype 1, 2 and 5 started to rise after the second injection, showed the highest titer at 30 days after injection and then gradually decreased in vaccinated pigs. The finishing rate in the vaccinated group was 91.6% and that in the control group immunized with commercial vaccine was 60%. The lungs in the control pigs showed severe pneumonia with hyperemia, pleural adhesion and abscess. In contrast, vaccinated pigs showed slight pneumonia. Injection scars were not observed in vaccinated pigs 100 days after the second injection. In conclusion, the pigs immunized with AP3V were sufficiently protected against A. pleuropneumoniae infection and the trial proved to be satisfactory in the safety of the vaccine under field conditions.

【 授权许可】

Unknown