Safety Test and Field Study of an Inactivated Oil-Adjuvanted H5N1 Avian Influenza Vaccine

Journal of Veterinary Medical Science

Masashi SAKAGUCHI²  Ryuichi SAKAMOTO²  Toshiaki OHGITANI¹  Akira SAWATA³  Takashi SASAKI¹  Takashi IMAMURA²  Norihide KOKUMAI¹  Zhifeng LIN⁴ 

[1] Avian Biologics Department, Kyoto Biken Laboratories, Inc.;Division 2, Second Research Department, The Chemo-Sero-Therapeutic Research Institute;Kitasato Institute Research Center for Biologicals;Research Department, Nippon Institute for Biological Science

关键词: avian influenza;    field trial;    H5N1;    safety test;    vaccine;   

DOI  :  10.1292/jvms.10-0091

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(16)We previously reported the development of an inactivated oil-adjuvanted avian influenza vaccine using an apathogenic H5N1 strain of the same lineage as the Eurasian lineage viruses currently epidemic in Asia. In this study, we confirmed the safety and evaluated the efficacy of this vaccine in layer chicken farms by field trials. No problematic adverse reactions occurred in the safety test. In addition, no adverse effects were observed in the field trial, and the antibody titer exceeded a protective level (hemagglutination inhibition (HI) antibody titer of 16) at 3 weeks after a single injection. Based on the above findings, this vaccine was confirmed to be safe and induced a protective level of antibody titer with a single injection in the chickens at the farms.

【 授权许可】

Unknown