Expression of regulatory dendritic cell-related cytokines in cattle experimentally infected with Trypanosoma evansi

Journal of Veterinary Medical Science

Claro Niegos MINGALA¹  Kazuhiko OHASHI²  Satoru KONNAI²  Shiro MURATA²  Hirohisa MEKATA² 

[1] Animal Health Unit, Philippine Carabao Center National Headquarters and Gene Pool, 3120 Nueva Ecija, Science City of Munoz, Philippines;Laboratory of Infectious Diseases, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Sapporo 060�?0818, Japan

关键词: cattle;    CCL8;    IL-10;    regulatory DC;    Trypanosoma evansi;   

DOI  :  10.1292/jvms.15-0066

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(22)Trypanosoma evansi causes wasting disease in many livestock. T. evansi infection gives rise to inflammatory immune responses, which contribute to the development of inflammation-associated tissue injury. We previously reported that regulatory dendritic cells (DCs), which act as potential regulators of inflammation, were activated in infected mice and transfer of regulatory DCs to infected mice prolonged their survival. However, the kinetics of regulatory DCs in cattle, which are natural hosts of T. evansi, remained unclear. In this study, we report that the expressions of CCL8 and IL-10, which promote the development of regulatory DCs, were up-regulated in cattle experimentally infected with T. evansi. This finding is potentially useful for studying the control strategy of T. evansi infection in cattle.

【 授权许可】

Unknown