In vivo and In vitro Tests Showing Sensitization to Japanese Cedar(Cryptomeria japonica) Pollen Allergen in Atopic Dogs

Journal of Veterinary Medical Science

Atsuhiko HASEGAWA²  Kenichi MASUDA⁵  Koichi OHNO⁵  Hajime TSUJIMOTO⁵  Douglas J. DEBOER¹  Shunsuke FUJIWARA⁵  Keigo KURATA⁵  Kohei YAMASHITA⁶  Saburo SAITO⁴  Masahiro SAKAGUCHI³ 

[1] Department of Medical Sciences,School of Veterinary Medicine,University of Wisconsin-Madison,Madison,WI 53706-1102,U.S.A.;Department of Pathobiology,Nihon University School of Veterinary Medicine,Kanagawa 252-8510,Japan;National Institute of Infectious Diseases,Tokyo 162-8640,Japan;Department of Molecular Immunology,Institute of DNA Medicine,The Jikei University School of Medicine,Tokyo 105-8461,Japan;Department of Veterinary Internal Medicine,Graduate School of Agricultural and Life Sciences,The University of Tokyo,Tokyo 113-8657,Japan;Pharmaceutical Research Laboratory,Hitachi Chemical,Ibaraki 317-8555,Japan

关键词: atopic dermatitis;    canine;    Japanese cedar pollen;    type I hypersensitivity;   

DOI  :  10.1292/jvms.62.995

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(23)Cited-By(33)Using both in vivo and in vitro tests, dogs with atopic dermatitis were examined for sensitization with Japanese cedar(Cryptomeria japonica, CJ)pollen allergen.Ten dogs with clinical manifestation of atopic dermatitis were shown to be sensitized to CJ pollen based on the results of intradermal skin test and serum antigen−specific IgE test.In vitro lymphocyte stimulation test showed blastogenic response after stimulation with crude antigen of CJ pollen in all of the 5 cases examined.The peripheral leukocytes showed increased histamine release after stimulation with crude antigen of CJ pollen in 2 cases examined.These data indicate that a proportion of dogs with atopic dermatitis is sensitized to CJ pollen in a cell−mediated manner and show immediate phase reaction of type I hypersensitivity.

【 授权许可】

Unknown