Metformin Protects Against Carbon Tetrachloride Hepatotoxicity in Mice

Journal of Pharmacological Sciences

Duncan H.F. Mak¹  Po-Yee Chiu¹  Michel K.T. Poon¹  Kam-Ming Ko¹ 

[1] Department of Biochemistry, The Hong Kong University of Science & Technology

关键词: metformin;    carbon tetrachloride;    glutathione;   

DOI  :  10.1254/jphs.93.501

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(8)In the present study, the hepatoprotective effect of metformin (Met), a dimethylbiguanide anti-hyperglycemic, was examined in a mouse model of liver damage induced by chronic repeated administration of carbon tetrachloride (CCl4) (5 μl/kg, twice a week for 12 weeks). Met, when given orally in drinking water at an estimated daily dose of 25 or 50 mg/kg for 10 weeks starting 2 weeks after CCl4 challenge, protected against CCl4 hepatotoxicity. The results indicate that the hepatoprotection afforded by Met treatment at a dose of 25 mg/kg against CCl4 toxicity may at least in part be mediated by the enhancement of mitochondrial glutathione redox status.

【 授权许可】

Unknown