Low circulating adiponectin levels are associated with insulin resistance in non-obese peritoneal dialysis patients

Endocrine Journal

Dong Eun Yoo¹  Mi Jung Lee¹  Tae-Hyun Yoo¹  Hyung Jung Oh¹  Shin-Wook Kang¹  Seung Jun Kim¹  Dong Ho Shin¹  Seung Hyeok Han¹  Dae Suk Han¹  Kyu Hun Choi¹ 

[1] Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea

关键词: Insulin resistance;    Non-obese;    Peritoneal dialysis;    Adipokine;    Chronic inflammation;   

DOI  :  10.1507/endocrj.EJ12-0032

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(48)Cited-By(5)In patients with end-stage renal disease (ESRD), circulating adipokine levels are increased due to decreased renal clearance, irrespective of obesity. However, whether adipokines play a role in the development of insulin resistance (IR) in non-obese ESRD patients is unknown. We conducted a cross-sectional study to identify factors associated with IR in 62 non-obese patients on peritoneal dialysis (PD). Non-obesity was defined as body mass index (BMI) <25 kg/m². IR was determined using homeostatic model assessment-IR (HOMA-IR). We also measured serum concentrations of adiponectin, leptin, resistin, high-sensitivity C-reactive protein (hsCRP), and IL-6. The average BMI of the study patients was 21.6 kg/m². When patients were divided into two groups according to the median value of HOMA-IR, serum adiponectin levels were significantly lower in patients with HOMA-IR > 1.85 than in those with HOMA-IR ≤1.85, whereas serum concentrations of leptin and resistin did not differ between the two groups. In addition, log-transformed HOMA-IR was negatively correlated with adiponectin (γ = -0.464, P < 0.001) and log-transformed high-density lipoprotein cholesterol (γ = -0.250, P = 0.050) and positively correlated with age (γ = 0.334, P = 0.008) and triglyceride (γ = 0.392, P = 0.002). However, resistin, log-transformed leptin and log-transformed hsCRP were not associated with HOMA-IR. In a multiple linear regression model, adiponectin was independently associated with HOMA-IR (β = -0.023, P = 0.015). In conclusion, this study suggests that low circulating adiponectin levels might be involved in IR even in non-obese patients undergoing PD.

【 授权许可】

Unknown