A Polymorphism Observed in the Experimentally Successful Peptide Vaccine Sequence Derived from Theileria sergenti Piroplasm Major Surface Antigen (p33)

Journal of Veterinary Medical Science

Kozo FUJISAKI⁶  Toshinari OKUMURA¹  Tsugihiko KAMIO³  Youichiro TERASAKA²  Shin-Ichiro KAWAZU³  Tokuji MIYAHARA⁵  Motonobu HIDA⁴  Yasuhiro HIROGARI³  Yutaka TERADA³ 

[1] Abashiri Livestock Hygiene Service Center;Kurayoshi Livestock Hygiene Service Center;National Institute of Animal Health;Ujiie Livestock Hygiene Service Center;The Chemo-Sero-Therapeutic Research Institute;Japan International Research Center for Agricultural Sciences

关键词: p33;    Theileria sergenti;    vaccine;   

DOI  :  10.1292/jvms.59.829

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(12)Cited-By(4)A polymorphism in the experimentally successful peptide vaccine sequence (EVVWKEKKEVKDLDA, amino acids 134-148) derived from the 33 kDa piroplasm major surface antigen (p33) of Theileria sergenti was examined. The vaccine sequences obtained by PCR amplification and sequencing of the p33 gene from a total of 15 parasite-infected cattle blood samples collected from 4 prefectures through Hokkaido to Kumamoto revealed the two major sequences (Ikeda and Chitose stock types) either of which was identified in all samples. Since the peptide vaccine develops the parasite species- or stock-specific immunity in the animals, an application of the two major peptide sequences as cocktailed vaccine should be evaluated for a practical use of this strategy to controlling T. sergenti infection in Japan.

【 授权许可】

Unknown