The relationship of epicardial adipose tissue thickness to clinical and biochemical features in women with polycystic ovary syndrome

Endocrine Journal

Baris Bugan⁵  Serkan Tapan⁴  Oben Baysan⁵  Ilker Tasci¹  Umit Aydogan²  Halil Akbulut²  Mustafa Kutlu³  Gokhan Uckaya³  Alper Sonmez³  Muhittin Serdar⁴  Sebnem Aydogdu⁶  Aydogan Aydogdu³ 

[1]Deparment of Internal Medicine, Gulhane School of Medicine, Ankara 06018, Turkey

[2]Deparment of Family Medicine, Gulhane School of Medicine, Ankara 06018, Turkey

[3]Department of Endocrinology and Metabolism, Gulhane School of Medicine, Ankara 06018, Turkey

[4]Department of Biochemistry, Gulhane School of Medicine, Ankara 06018, Turkey

[5]Deparment of Cardiology, Gulhane School of Medicine, Ankara 06018, Turkey

[6]Deparment of Internal Medicine, Mevki Military Hospital, Ankara 06018, Turkey

关键词: Polycystic ovary syndrome;    Epicardial adipose tissue thickness;    Adiponectin;    Insulin resistance;    Cardiovascular disease;   

DOI  :  10.1507/endocrj.EJ11-0328

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(36)Cited-By(6)The amount of epicardial adipose tissue (EAT), a component of body visceral adiposity, has been linked to the presence and severity of cardiovascular disease through multiple mechanisms.Polycystic ovary syndrome (PCOS) is characterized by insulin resistance and subclinical inflammation, which participate in the mechanism of atherosclerosis.We searched if the patients with PCOS have increased EAT thickness (EATT), along with its relation to the measures of adiposity and insulin sensitivity.A total of 41 subjects with PCOS and 46 age and body mass index (BMI) matched healthy controls were enrolled.EAT was measured by echocardiography above the free wall of the right ventricle.Insulin resistance was assessed by homeostasis model assessment of insulin resistance (HOMA-IR) formula, and plasma adiponectin level was measured by ELISA.Compared to healthy controls EATT and HOMA-IR score were significantly higher (p=0.0001 for both) while plasma adiponectin concentration was significantly lower (p=0.048) in women with PCOS.EATT correlated positively with total cholesterol, triglyceride, luteinizing hormone (LH) and negatively with sex hormon binding globuline (pp=0.924).Triglyceride level was the significant determinant of EATT in logistic regression analysis (p=0.035).Thickness of the EAT is increased in patients with PCOS in conjunction with hyperandrogenity.Prospective studies are required to identify the relation of EAT and cardiovascular risk in patients with PCOS.

【 授权许可】

Unknown