Antibody Responses Induced by Japanese Whole Inactivated Vaccines against Equine Influenza Virus (H3N8) Belonging to Florida Sublineage Clade2

Journal of Veterinary Medical Science

Takashi YAMANAKA¹  Koji TSUJIMURA¹  Manabu NEMOTO¹  Hiroshi BANNAI¹  Tomio MATSUMURA¹  Takashi KONDO¹ 

[1] Epizootic Research Center, Equine Research Institute, Japan Racing Association

关键词: equine influenza;    Florida sublineage;    vaccine;   

DOI  :  10.1292/jvms.10-0408

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(23)Cited-By(5)In 2010, the World Organisation for Animal Health recommended the inclusion of a Florida sublineage clade2 strain of equine influenza virus (H3N8), which is represented by A/equine/Richmond/1/07 (Richmond07), in equine influenza vaccines. Here, we evaluate the antigenic differences between Japanese vaccine strains and Richmond07 by performing hemagglutination inhibition (HI) assays. Ferret antiserum raised to A/equine/La Plata/93 (La Plata93), which is a Japanese vaccine strain, reacted with Richmond07 at a similar titer to La Plata93. Moreover, two hundred racehorses exhibited similar geometric mean HI antibody titers against La Plata93 and Richmond07 (73.1 and 80.8, respectively). Therefore, we can expect the antibody induced by the current Japanese vaccines to provide some protection against Richmond07-like viruses.

【 授权许可】

Unknown