Effects of Quaternary Ammonium Compounds with 0.1% Sodium Hydroxide on Swine Vesicular Disease Virus

Journal of Veterinary Medical Science

Toru INOUE²  Junsuke SHIRAI²  Reiji SEKI¹  Toru KANNO²  Satoru MITSUBAYASHI¹ 

[1] Tamura Pharmaceutical Co., Ltd.;Department of Exotic Diseases, National Institute of Animal Health

关键词: disinfection;    electron microscopy;    0.1% NaOH;    quaternary ammonium compound;    swine vesicular disease virus;   

DOI  :  10.1292/jvms.59.323

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(15)Cited-By(5)The effects of quaternary ammonium compounds (QACs) with sodium hydroxide on swine vesicular disease virus (SVDV), an enterovirus were studied. Didecyldimethylammonium chloride (DDAC) with 0.1% NaOH showed a stronger effect against SVDV than other QACs with 0.1% NaOH. The effect of DDAC with 0.1% NaOH was strong at 40°C. DDAC was effective against SVDV at pH values around 11.0, but not in the distilled water control. The effect of DDAC with 0.1% NaOH was already observed at 1 min after mixing of the DDAC with SVDV. Observation under an electron microscopy revealed that the probable mechanism of inactivation of DDAC with 0.1% NaOH is as follows: The virus particles were partially destroyed by 0.1% NaOH. DDAC gathered these affected particles and formed a micelle, then SVDV lost its infectivity. From these results, QACs with 0.1% NaOH are considered to be very effective against SVDV representing enteroviruses.

【 授权许可】

Unknown