Virucidal activity of a quaternary ammonium compound associated with calciumhydroxide on avian influenza virus, Newcastle disease virus and infectious bursal diseasevirus

The Journal of Veterinary Medical Science

Miyuki KOMURA¹  Natthanan SANGSRIRATAKUL¹  Satoru TAKAHASHI¹  Md. Shahin ALAM¹  Mariko ITO¹  Dany SHOHAM¹  Mayuko SUZUKI²  Kazuaki TAKEHARA² 

[1] Laboratory of Animal Health, Department of VeterinaryMedicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology,3-5-8, Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan;The United Graduate School of Veterinary Science, GifuUniversity, 1-1, Yanagido, Gifu 501-1193, Japan

关键词: food additive grade calcium hydroxide (FdCa(OH)2);    poultry viral pathogens;    quaternary ammonium compound;    synergistic effects;    virucide;   

DOI  :  10.1292/jvms.18-0006

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

A quaternary ammonium compound (QAC) was evaluated for its virucidal efficacies with foodadditive grade calcium hydroxide (FdCa(OH)2). When the QAC was diluted 1500(QACx500) with redistilled water (dW2), it inactivated avian influenza virus(AIV) within 30 sec at 25°C, while at 2°C, it required 1 hr for inactivation. WhenFdCa(OH)2 powder was added to QACx500 at a final concentration of 0.17%, themixture, namely Mix500, inactivated AIV within 3 min at 2°C. After contamination with 1%fetal bovine serum (FBS), Mix500 inactivated AIV within 2 hr at 2°C, but QACx500 did not.These results indicate synergistic effects of the QAC and FdCa(OH)2 solutionson virucidal activity.

【 授权许可】

Unknown