ANTXR-1 and -2 independent modulation of a cytotoxicity mediated by anthraxtoxin in human cells

Journal of Veterinary Medical Science

Kochi TOYOMANE¹  Etsuko MIFUNE¹  Daisuke FUJIKURA¹  Miyuki OHNUMA¹  Kozue KAMIYA¹  Hideaki HIGASHI¹  Memi MUTOH¹ 

[1] Division of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido University, Kita-20, Nishi-10, Kita-ku, Sapporo, Hokkaido 001�?0020, Japan

关键词: anthrax;    ANTXRs;    cell death;    macrophage;    toxin;   

DOI  :  10.1292/jvms.15-0727

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(22)Several animal models have shown that anthrax toxin (ATX) elicits a cytotoxic effect onhost cells through anthrax toxin receptor (ANTXR) function. In this study, compared withmouse cells, cells obtained from humans exhibited low sensitivity to ATX-mediatedcytotoxicity, and the sensitivity was not correlated with expression levels of ANTXRs. ATXtreatment also induced a cytotoxic effect in other cultured human cells, human embryonickidney (HEK) 293 cells, that express ANTXRs at undetectable levels. Furthermore, ectopicexpression of ANTXRs in HEK293 cells did not affect the sensitivity to ATX treatment.These findings suggest that there is an ANTXR-independent cytotoxic mechanism in humancells.

【 授权许可】

Unknown