Involvement of Histamine Released From Mast Cells in Acute Radiation Dermatitis in Mice

Journal of Pharmacological Sciences

Atsushi Yamatodani¹  Naoko Kureyama¹  Keita Okamura¹  Saiko Moriyasu¹  Toshiji Ikeda²  Kouichi Yamamoto¹ 

[1] Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Japan;Department of Accelerator Science, The Institute of Scientific and Industrial Research, Osaka University, Japan

关键词: radiation dermatitis;    histamine;    mast cell;   

DOI  :  10.1254/jphs.SC0070127

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(14)Cited-By(10)A possible involvement of histamine in acute radiation dermatitis in mice was investigated. The dose of 40 Gy of gamma irradiation induced erythema and edema in C57BL/6 mice treated with vehicle. However, in C57BL/6 mice treated with chlorpheniramine and WBB6F1-W/Wv mice, erythema and edema were not observed. In all of these mice, epilation and dry desquamation were induced, but bepotastine significantly reduced the extent of these areas. These results suggest that gamma irradiation-induced erythema and edema were caused by histamine released from mast cells via histamine H1 receptor, and epilation was induced by other inflammatory mediators.

【 授权许可】

Unknown