Histamine and TNF-α release by rat peritoneal mast cells stimulated with Trichomonas vaginalis

Parasite

and J.S. Ryu¹  H.M. Kim³  Y.S. Kim⁴  H.O. Song²  I.H. Han¹  M.H. Ahn¹  S.J. Im¹ 

[1] Department of Environmental Biology and Medical Parasitology, Hanyang University College of Medicine,#17 Haengdang-dong, Sungdong-gu, Seoul 133-791,Korea;Department of Parasitology, School of Medicine, Catholic University of Daegu,Daegu 705-718,Korea;Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University,Seoul 130-701,Korea;Department of Biochemistry and Molecular Biology, Hanyang University College of Medicine,Seoul 133-791,Korea

关键词: TNF-α;    histamine;    migration;    mast cell;    rat;    Trichomonas vaginalis;   

Others  :  808884
DOI  :  doi:10.1051/parasite/2011181049

 received in 2010-07-07, accepted in 2010-10-01,  发布年份 2011

【 摘 要 】

Mast cells have been reported to be predominant in the vaginal smears of patients infected with T. vaginalis. In this study, we investigated whether T. vaginalis could induce mast cells to migrate and to produce TNF-α and histamine. Rat peritoneal mast cells (RPMC), a primary mast cell, were used for the study. T. vaginalis induced an increase in chemotactic migration of the mast cells toward excretory and secretory product (ESP) of T. vaginalis, and the mast cells activated with T. vaginalis showed an increased release of histamine and TNF-α. Therefore, mast cells may be involved in the inflammatory response caused by T. vaginalis.

【 授权许可】

   
© PRINCEPS Editions, Paris, 2011

【 图 表 】

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