Effects of Therapy on Anterior Pituitary Functions in Patients with Primary Intracranial Germ Cell Tumor

Endocrine Journal

MASAFUMI KOGA²  SOJI KASAYAMA²  TORU HAYAKAWA¹  BUNZO SATO²  HARUHIKO KOUHARA²  ATSUSHI KUMANOGOH²  NORIO ARITA¹  TADAMITSU KISHIMOTO² 

[1] Departments of Neurosurgery, Osaka University Medical School;Departments of Medicine III, Osaka University Medical School

关键词: Intracranial germ cell tumors;    Radiotherapy;    Chemotherapy;    Hormonal remission;   

DOI  :  10.1507/endocrj.41.287

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(24)Cited-By(7)Intracranial germ cell tumors are known to be frequently associated with anterior pituitary hypofunction and diabetes insipidus. In general, these manifestations are not ameliorated even after successful radiotherapy. Since platinum based chemotherapy is introduced as a therapeutic approach to these tumors, its effectiveness is compared with the outcome obtained by radiotherapy in terms of tumor regression and endocrine functions. In this study, six patients received conventional radiotherapy and one received chemotherapy as an initial treatment. In all patients, complete remission was achieved irrespective of the therapeutic method. Their diabetes insipidus was not improved. Many patients treated with radiotherapy did not show the complete improvement of pre-existing hypofunction of the anterior pituitaries. In contrast, chemotherapy achieved almost complete hormonal remission. These clinical observations suggest that chemotherapy is quite effective in oncological as well as endocrino-logical aspects in treating intracranial germ cell tumors.

【 授权许可】

Unknown