Synthesis and Biological Activity of Reversed Pyrimidine Nucleosides

Croatica Chemica Acta

Glavaš-Obrovac, Ljubica¹  Matić, Josipa²  Žinić, Biserka²  Ban, Željka²  Župančić, Nataša³  Saftić, Dijana² 

[1] Department of Clinical Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine, J. J. Strossmayer University of Osijek, Huttlerova 4,31000 Osijek, Croatia;Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia;TAPI Research and Development, PLIVA Croatia Ltd., Prilaz baruna Filipovića 25, 10 000 Zagreb, Croatia

关键词: uracil;    5-halogenuracil;    D-ribose;    reversed nucleosides;    antitumor activity;   

DOI  :  

学科分类：化学（综合）

来源: Croatica Chemica Acta

【 摘 要 】

An efficient approach to reversed nucleosides which enables their synthesis in gram quantities is described. N-1�?-Pyrimidine reversed nucleosides were prepared by treating of the sodium salt of pyrimidine bases with protected 5-tosyl...

【 授权许可】

Unknown