Effects of Erythropoietin on Cardiac Remodeling After Myocardial Infarction

Journal of Pharmacological Sciences

Hiroshi Iwao³  Takashi Omura¹  Kazuhide Takeuchi¹  Ryo Matsumoto¹  Soichiro Enomoto¹  Minoru Yoshiyama¹  Daisuke Nishiya¹  Kenei Shimada²  Junichi Yoshikawa²  Takanori Kusuyama¹ 

[1] Department of Internal Medicine and Cardiology, Osaka City University Medical School, Japan;Department of Medicine Cardiovascular Division, Osaka Ekisaikai Hospital, Japan;Department of Pharmacology, Osaka City University Medical School, Japan

关键词: myocardial infarction;    cardiac remodeling;    erythropoietin;    angiogenesis;    apoptosis;   

DOI  :  10.1254/jphs.FP0050966

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(27)Cited-By(38)Erythropoietin (EPO) has been suggested to have a cardioprotective effect against ischemia. The purpose of this study was to examine the effects of EPO on cardiac remodeling after myocardial infarction (MI). MI was induced by ligation of the coronary artery in Wistar rats. The rats with MI were randomly divided into untreated MI and two EPO-treated MI groups. EPO was administered subcutaneously by injection once a day for 4 days after MI at 5000 U/kg or 3 times a week for 4 weeks at 1000 U/kg. Five days after MI, EPO prevented the increase in activated caspase 3, matrix metalloproteinase-2, and transcriptional activation of activator protein-1 in non-infarcted myocardium. Four weeks after MI, left ventricular weight, left ventricular end-diastolic pressure, and left ventricular dimension were increased, and ejection fraction and E wave deceleration time were decreased. EPO significantly attenuated this ventricular remodeling and systolic and diastolic dysfunction. In addition, EPO significantly attenuated the interstitial fibrosis and remodeling-related gene expression in non-infarcted myocardium. Furthermore, EPO significantly enhanced angiogenesis and reduced apoptotic cell death in peri-infarcted myocardium. In conclusion, when administered after MI, EPO prevents cardiac remodeling and improves ventricular function with enhanced angiogenesis and reduced apoptosis.

【 授权许可】

Unknown