Journal of Pharmacological Sciences | |
Inhibitory Effect of Zacopride on Cisplatin-Induced Delayed Emesis in Ferrets | |
Hisashi Yamakuni1  Masahiko Matsuo1  Katsunori Imazumi1  Shigeo Matsui1  Hiroe Nakayama1  Seitaro Mutoh1  | |
[1] Department of Urology, Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Japan | |
关键词: 5-HT4 receptor; 5-HT3 receptor; delayed emesis; | |
DOI : 10.1254/jphs.SCJ05007X | |
学科分类:药学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(11)Cited-By(7)We evaluated the antiemetic effect of zacopride, a potent 5-HT3-receptor antagonist with 5-HT4-receptor agonist properties, on delayed emesis caused by cisplatin (5 mg/kg, i.p.) in ferrets, compared with granisetron, a selective 5-HT3-receptor antagonist. Multiple intravenous injections of zacopride at 1 mg/kg, a dose that completely inhibited acute emesis caused by cisplatin (10 mg/kg, i.v.), significantly reduced delayed emesis. Granisetron (3.2 mg/kg) also reduced delayed emesis but this failed to reach statistical significance. The present study suggests that a combined 5-HT3-receptor antagonist / 5-HT4-receptor agonist, like zacopride, may be useful against both acute and delayed emesis induced by cancer chemotherapy.
【 授权许可】
Unknown
【 预 览 】
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RO201911300267251ZK.pdf | 143KB | download |