期刊论文详细信息
Journal of Pharmacological Sciences
Inhibitory Effect of Zacopride on Cisplatin-Induced Delayed Emesis in Ferrets
Hisashi Yamakuni1  Masahiko Matsuo1  Katsunori Imazumi1  Shigeo Matsui1  Hiroe Nakayama1  Seitaro Mutoh1 
[1] Department of Urology, Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Japan
关键词: 5-HT4 receptor;    5-HT3 receptor;    delayed emesis;   
DOI  :  10.1254/jphs.SCJ05007X
学科分类:药学
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society
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【 摘 要 】

References(11)Cited-By(7)We evaluated the antiemetic effect of zacopride, a potent 5-HT3-receptor antagonist with 5-HT4-receptor agonist properties, on delayed emesis caused by cisplatin (5 mg/kg, i.p.) in ferrets, compared with granisetron, a selective 5-HT3-receptor antagonist. Multiple intravenous injections of zacopride at 1 mg/kg, a dose that completely inhibited acute emesis caused by cisplatin (10 mg/kg, i.v.), significantly reduced delayed emesis. Granisetron (3.2 mg/kg) also reduced delayed emesis but this failed to reach statistical significance. The present study suggests that a combined 5-HT3-receptor antagonist / 5-HT4-receptor agonist, like zacopride, may be useful against both acute and delayed emesis induced by cancer chemotherapy.

【 授权许可】

Unknown   

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