Circulating Tumor Necrosis Factor and Interleukin-1 after Administration of LPS in Adult Cows

Journal of Veterinary Medical Science

Motoshi TAJIMA³  Takuya TANAKA¹  Hiromichi OHTSUKA¹  Tomo-o YOSHINO²  Kiyoshi AKAHASHI¹  Kenji OHKI¹ 

[1] Department of Veterinary Internal Medicine, Rakuno Gakuen University;Department of Veterinary Pathology, Faculty of Veterinary Medicine, Rakuno Gakuen University;Department of Veterinary Internal Medicine, School of Veterinary Medicine, Hokkaido University

关键词: bovine;    cytokine;    lipopolysaccharide;   

DOI  :  10.1292/jvms.59.927

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(13)Cited-By(15)This study examined the levels of serum tumor necrosis factor (TNF), interleukin-1 (IL-1) and plasma cortisol levels in adult cows after intravenous administration of lipopolysaccharide (LPS) extracted from Escherichia coli. The adult cows exhibited clinical signs of endotoxic shock. The mean concentrations of serum TNF was 557.9 U/ml and serum IL-1 was 90.6 U/ml at 2 hr after LPS administration following severe endotoxic shock. Plasma cortisol concentrations increased immediately and a peak level was 131.4 ng/m l at 1 hr after LPS challenge. These results suggested that circulating concentrations of TNF, IL-1, and cortisol may be associated with clinical signs of endotoxemia in adult cows.

【 授权许可】

Unknown