Borna Disease Virus Infection in Domestic Cats: Evaluation by RNA and Antibody Detection

Journal of Veterinary Medical Science

Takashi KIMURA²  Reiko IIZUKA¹  Motonobu HARA⁴  Yoshii NISHINO⁵  Masayuki FUNABA³  Ryoko FUKUSHIMA⁵  Tetsuya MIZUTANI⁶  Hiroshi HIRAMI¹ 

[1] Hirami Animal Hospital, 10-23 Tateno-cho, Nerima-Ku, Tokyo 177-0054, Japan;Comparative Pathology, Department of Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita-18, Nishi-9, Kita-Ku, Sapporo 060-0818, Japan;Departments of Nutrition, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Sagamihara 229-8501, Japan;Departments of Veterinary Microbiology II, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Sagamihara 229-8501, Japan;Research Institute of Biosciences, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Sagamihara 229-8501, Japan;Laboratories of Public Health, Department of Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita-18, Nishi-9, Kita-Ku, Sapporo 060-0818, Japan

关键词: Borna disease virus;    feline;    infection;   

DOI  :  10.1292/jvms.61.1167

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(31)Cited-By(14)Borna disease virus (BDV) infection has been suggested to cause spontaneous neurological disease in cats referred to as staggering disease. However the evaluation of BDV infection in neurologically asymptomatic cats remained unclear. In the present study, BDV infected, asymptomatic cats in Tokyo were surveyed both by the presence of plasma antibodies against BDV-p24 and -p40 and by RNA detection in peripheral blood mononuclear cells. Seven of 32 domestic cats (21.9%) were serologically or genetically judged to be BDV-infected. Six cats were positive for anti-BDV antibody and two cats were positive for BDV RNA. Within the 2 RNA-positive cats, only one was positive for anti-BDV antibodies. Furthermore, the findings of anti-BDV-p40 and anti-BDV-p24 antibody-positive cats did not completely overlap. These results suggest that there are neurologically asymptomatic domestic cats infected with BDV present in the Tokyo area.

【 授权许可】

Unknown