期刊论文详细信息
Croatica Chemica Acta | |
Large-scale Solution Synthesis of Phosphorothioate Oligonucleotides: A Comparison of the Phosphoro-amidite and Phosphotriester Dimeric Approaches | |
Bonora, Gian Maria1  Ravikumar, Vasulinga3  Zaramella, Simone2  | |
[1] Department of Chemical Sciences, University of Trieste, Via Giorgieri 1, Trieste, Italy;MBB, Karolinska Institutet, Stockolm, Sweden;ISIS Pharmaceutical, Carlshad, California, USA | |
关键词: oligonucleotides; phosphorothioate; scale up; large-scale; synthesis; phosphoramidite; phosphotriester; liquid-phase; polyethylene glycol; | |
DOI : | |
学科分类:化学(综合) | |
来源: Croatica Chemica Acta | |
【 摘 要 】
Two different approaches to the solution synthesis of oligonucleotides are compared. Both procedures use dimer synthons as building blocks to save time and to improve the final product yield and quality. These strategies look quite...
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201911300246706ZK.pdf | 79KB | download |