Large-scale Solution Synthesis of Phosphorothioate Oligonucleotides: A Comparison of the Phosphoro-amidite and Phosphotriester Dimeric Approaches

Croatica Chemica Acta

Bonora, Gian Maria¹  Ravikumar, Vasulinga³  Zaramella, Simone² 

[1] Department of Chemical Sciences, University of Trieste, Via Giorgieri 1, Trieste, Italy;MBB, Karolinska Institutet, Stockolm, Sweden;ISIS Pharmaceutical, Carlshad, California, USA

关键词: oligonucleotides;    phosphorothioate;    scale up;    large-scale;    synthesis;    phosphoramidite;    phosphotriester;    liquid-phase;    polyethylene glycol;   

DOI  :  

学科分类：化学（综合）

来源: Croatica Chemica Acta

【 摘 要 】

Two different approaches to the solution synthesis of oligonucleotides are compared. Both procedures use dimer synthons as building blocks to save time and to improve the final product yield and quality. These strategies look quite...

【 授权许可】

Unknown