Hodgkin Lymphoma in Temporal Association with Growth Hormone Replacement

Endocrine Journal

Vera MALKOVSKA³  Renee J. FREEDMAN²  Michael T. COLLINS¹  Derek LeROITH⁴ 

[1] Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services;Developmental Endocrinology Branch, National Institute of Child Health and Human Development;Washington Cancer Institute, Washington Hospital Center;Clinical Endocrinology Branch, National Institute of Diabetes, Digestive and Kidney Diseases

关键词: Hematology;    Malignancy;    Hormones;    Panhypopituitary;   

DOI  :  10.1507/endocrj.52.571

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(25)Cited-By(4)The association between growth hormone (GH) replacement and malignancy has long been debated. We report a case of Hodgkin lymphoma that developed in temporal association with the initiation of GH replacement in a 57-year-old woman with panhypopituitarism secondary to a non-secretory pituitary macroadenoma. Treatment of her pituitary tumor included transphenoidal surgery, external beam radiation, Bromocriptine and Cabergaline therapy. In addition to replacement steroid, thyroid and sex hormones, she insisted on GH replacement. Approximately 2 years after GH initiation, the diagnosis of Hodgkin lymphoma was made. Although the exact contribution of GH to the development of Hodgkin disease in our patient is unclear and a causal effect cannot be concluded, the temporal association is suggestive, and warrants reporting as part of ongoing surveillance for potential complications of GH replacement.

【 授权许可】

Unknown