Downregulation of phospho‐tyrosine phosphatases in a macrophage tumor

FEBS Letters

Sridhar, T.S.¹  Khar, Ashok¹  Swarup, G.¹ 

[1] Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India

关键词: Phospho-tyrosine phosphatase;    Downregulation;    Malignancy;    Rat macrophage cell line;   

DOI  :  10.1016/0014-5793(93)81764-Q

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We provide evidence for the downregulation of phospho-tyrosine phosphatases (PTPases) in malignancy. AK-5, a rat macrophage tumor, shows the downregulation of the transcripts of two non-receptor-type PTPases, PTP-1 and PTP-S. Though downregulated fourfold, the genomic organization of PTP-S is unaltered. There is no gross alteration of the PTPase activity in AK-5 as compared to macrophages. Immunoblot analysis reveals no significant change in the total phospho-tyrosine levels in AK-5, but there is a qualitative difference in the pattern between AK-5 and macrophages. Our results lend credence to the conjecture that PTPases also might be involved in malignancy.

【 授权许可】

Unknown