A Case of Growth Failure Caused by 13-CIS-Retinoic Acid Administration after Bone Marrow Transplantation for Neuroblasoma

Endocrine Journal

HIDEO MUGISHIMA¹  TAKASHI SUZUKI¹  YASUJI INAMO² 

[1] Department of Pediatrics, Nihon University School of Medicine;Department of General Pediatrics, Nihon University Nerima-Hikarigaoka Hospital

关键词: Growth failure;    13-cis-retinoic acid;    Premature epiphyseal closure;    Cancer therapy;   

DOI  :  10.1507/endocrj.46.Suppl_S113

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(2)Cited-By(5)We report an 11-year-old girl with growth failure caused by long-term administration of 13-cis-retinoic acid after bone marrow transplantation for neuroblastoma. Her growth velocity was 1-2 cm/year after 13-cis-retinoic acid administration. Her endocrinological findings were normal except for peak growth hormone levels of 6.4ng/ml (clonidine) and 9.7ng/ml (arginine). IGF-1 and IGFBP-3 were normal. It is not possible to conclude that her severe growth failure was caused by partial growth hormone deficiency, but premature epiphyseal closure was seen on radiographic examination. We concluded that the growth failure was caused by pediatric cancer therapy for the musculoskeletal system but not by endocrinological disturbance.

【 授权许可】

Unknown