Four Patients with Polyendocrinopathy with Associated Pituitary Hormone Deficiency

Endocrine Journal

KOZO HASHIMOTO¹  HISAYO KUROKAWA¹  KAZUNAGA TAKAMATSU¹  TATSUYA NISHIOKA¹  KYOKO TAKEDA¹  TOSHIHIRO TAKAO¹  YUKIKO NUMATA¹ 

[1] Second Department of Internal Medicine, Kochi Medical School

关键词: IDDM;    Hashimoto's disease;    Isolated ACTH deficiency;    TSH;    Gonadotropin;   

DOI  :  10.1507/endocrj.41.613

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(17)Cited-By(11)Four cases of polyglandular endocrine disorders associated with pituitary hormone secretion failure are reported. Three of them had both insulin dependent diabetes mellitus (IDDM) and Hashimoto's disease. Each of these patients (cases 1-3) showed isolated deficiency of ACTH, TSH or gonadotropin, respectively. Another patient (case 4) had both Hashimoto's disease and isolated ACTH deficiency. Anti-pituitary antibody to AtT-20 cells was detected in case 1. Serum gamma-globulins from patients 1 and 4 attenuated corticotropin releasing hormone-induced ACTH release in monolayer cultured rat anterior pituitary cells. Gamma-globulins from patients 1 and 2 decreased baseline TSH release but stimulated baseline prolactin release in pituitary cell cultures. It is possible that pituitary hormone deficiency in these patients may be caused by autoimmune disorders.

【 授权许可】

Unknown