Multiple Endocrine Disorders and Rathke’s Cleft Cyst with Klinefelter’s Syndrome: A Case Report

Endocrine Journal

SANAE MIDORIKAWA³  SUSUMU NIIMURA³  JUNKO NAKANO⁴  MITSUHIRO GOTOH⁴  KENJI MIZUNO¹  YOSHIAKI ONO² 

[1] Department of Ecology and Clinical Therapeutics, Fukushima Medical University School of Nursing;Department of Internal Medicine, Fujita Municipal General Hospital;Department of Internal Medicine III, Fukushima Medical University School of Medicine;Department of Internal Medicine, Yanagawa Municipal Hospital

关键词: Rathke’s cleft cyst;    Klinefelter’s syndrome;    Partial diabetes insipidus;    Type 2 diabetes mellitus;    Low renin essential hypertension;   

DOI  :  10.1507/endocrj.49.523

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(35)Cited-By(2)A 46-year-old Japanese male was admitted for the evaluation of severe hypertension. He was obese and had a eunuchoidal body habitus. Chromosomal analysis revealed a 46, XY/47, XXY karyotype. Serum LH, FSH and testosterone levels were low, indicating hypogonadotropic hypogonadism. Endocrinological dynamic tests disclosed presence of hypothalamic panhypopituitarism, partial diabetes insipidus, type 2 diabetes mellitus and low renin essential hypertension. Brain computed tomography and magnetic resonance imaging revealed intra- and extrasellar masses. Histological examination of the tissue obtained at transsphenoidal surgery showed a Rathke’s cleft cyst (RCC). To the best of our knowledge, this is the first case report of mosaic Klinefelter’s syndrome accompanied by symptomatic RCC, type 2 diabetes mellitus and low renin essential hypertension.

【 授权许可】

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