Topics on the Na+/Ca2+ Exchanger:Involvement of Na+/Ca2+ Exchanger in the Vasodilator-Induced Vasorelaxation

Journal of Pharmacological Sciences

Junji Nishimura¹ 

[1] Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Japan

关键词: cyclic AMP;    cyclic GMP;    intracellular Ca2+ concentration;    Na+/Ca2+ exchanger;    vascular smooth muscle;   

DOI  :  10.1254/jphs.FMJ06002X5

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(58)Cited-By(6)Many kinds of vasodilators induce relaxation of the vascular smooth muscle cells (VSMCs) through the production of cyclic AMP (cAMP) or cyclic GMP (cGMP). The relaxant effects mediated by these second messengers are thought to be mainly due to the decrease in intracellular Ca2+ concentration ([Ca2+]i), as well as the decrease in Ca2+ sensitivity of the contractile apparatus of VSMCs. To explain the cAMP- or cGMP-mediated decrease in [Ca2+]i, several mechanisms have been proposed, including the inhibition of Ca2+ influx due to a hyperpolarization, a stimulation of Ca2+ uptake into the intracellular store, and an increase in Ca2+ extrusion from VSMCs by stimulation of sarcolemmal Ca2+-pump. VSMCs have two major systems for Ca2+ extrusion, namely, sarcolemmal Ca2+-pump and Na+/Ca2+ exchanger (NCX). However, the involvement of NCX in the vasodilator-induced relaxation of VSMCs has not been well established. In this article, the possible involvement of NCX in the vasodilator-induced relaxation of VSMCs will be reviewed.

【 授权许可】

Unknown